2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-167853
    KR-31080 174800-22-7 98%
    KR-31080 is an derivative of imidazo [4,5-b] pyridine. KR-31080 inhibits angiotensin II receptor. KR-31080 inhibits the NO production in LPS-stimulated BV-2 cells at a concentration of 2 μm with inhibition of 8.3%.
    KR-31080
  • HY-167906
    Lunamarine 483-52-3 98%
    Lunamarine is a inhibitor of PDE5 with BBB permeability. Lunamarine can be used in the reseach of Pulmonary Arterial Hypertension (PAH) and Erectile Dysfunction (ED).
    Lunamarine
  • HY-167950
    PPARα/γ agonist 5 849150-59-0 98%
    PPARα/γ agonist 5 is a dual PPARα/γ agonist with significant biological activity exhibited at low concentrations. The EC50 of PPARα/γ agonist 5 are 0.358μM and 1.21μM respectively, showing its potential in inhibiting type 2 diabetes and lipid metabolism disorders. PPARα/γ agonist 5 was selected for clinical development due to its high efficacy.
    PPARα/γ agonist 5
  • HY-168103
    FBPase-IN-3 3102011-46-8 98%
    FBPase-IN-3 (compound 45) is a FBPase (fructose-1,6-bisphosphatase) inhibitor with an IC50 of 2.08 μM. FBPase-IN-3 exhibits potent inhibitory activity of gluconeogenesis.
    FBPase-IN-3
  • HY-168393
    1,3-Dipalmitoyl-2-stearoyl glycerol 2177-97-1 98%
    1,3-Dipalmitoyl-2-stearoyl glycerol (1,3-Palmitin-2-stearin) is a triacylglycerol in which palmitic acid (HY-N0830) is located at the sn-1 and sn-3 positions, and stearic acid (HY-B2219) is at the sn-2 position. The levels of 1,3-Dipalmitoyl-2-stearoyl glycerol are associated with energy depletion caused by reduced food intake in rats.
    1,3-Dipalmitoyl-2-stearoyl glycerol
  • HY-168434
    Urease-IN-19 98%
    Urease-IN-19 (Compound 3c) is a potent urease inhibitor with an IC50 value of 2.7 µM. Urease-IN-19 is promising for research of kidney stones and stomach ulcers.
    Urease-IN-19
  • HY-168523
    S1647 259528-99-9 98%
    S1647 is a ASBT and SOAT dual inhibitor. S1647 can be used in the study of intrahepatic cholestasis, cholestatic pruritus, and obstipation.
    S1647
  • HY-168585
    GLP-1R agonist 26 3058090-73-3 98%
    GLP-1R agonist 26 (compound 1) is a glucagon-like peptide-1 receptor (GLP-1R) agonist with an EC50 of <10 nM.
    GLP-1R agonist 26
  • HY-168629
    FXR agonist 9 2982502-32-7 98%
    FXR agonist 9 (compound 26) is an oral active and selectivity FXR partial agonist with the EC50 of 0.09 µM (75.13 % maximum efficacy). FXR agonist 9 ameliorates pathological features in HFD and CCl4(HY-Y0298)-induced metabolic dysfunction-associated steatohepatitis mice.
    FXR agonist 9
  • HY-168740
    URAT1 inhibitor 11 2416416-13-0 98%
    URAT1 inhibitor 11 (Compound 7) is a URAT1 inhibitor with an IC50 value of 0.18 μM. URAT1 inhibitor 11 exhibits potent hypouricemic effects in hyperuricemic zebrafish induced by Potassium oxonate (HY-17511) and Xanthine sodium salt (HY-W017389).
    URAT1 inhibitor 11
  • HY-168759
    11α-Hydroxytestosterone 3066-12-4 98%
    11α-Hydroxytestosterone is a deriviative of Hydrocortisone (HY-N0583), with the relative binding affinity to progesterone receptor of 9% (comparing to R5020 (HY-119384) 100%). 11α-Hydroxytestosterone inhibits the growth and differentiation of human decidual cells in culture.
    11α-Hydroxytestosterone
  • HY-168781
    Arachidoyl glycine 617703-96-5 98%
    Arachidoyl glycine is composed of a 0:0 fatty acid with glycine attached to its carboxyl terminus.
    Arachidoyl glycine
  • HY-168784
    LTD4 antagonist 2 107813-86-5 98%
    LTD4 antagonist 2 (compound 6) is a leukotriene D4 (LTD4) antagonist with an IC50 of 2.8 μM against cysteinyl leukotriene 1 receptor (CysLT1R). LTD4 antagonist 2 is also a G protein-coupled bile acid receptor 1 (GPBAR1) agonist and can be utilized in research related to colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases.
    LTD4 antagonist 2
  • HY-168787
    1,3-Dieicosapentaenoyl glycerol 140670-41-3 98%
    1,3-Dieicosapentaenoyl glycerol is a diacylglycerol that contains Eicosapentaenoic acid (HY-B0660) at the sn-1 and sn-3 positions.
    1,3-Dieicosapentaenoyl glycerol
  • HY-168792
    (±)-9-Nor-9α-hydroxy Hexahydrocannabinol 56469-26-2 98%
    (±)-9-Nor-9α-hydroxy Hexahydrocannabinol is a cannabinoid-type compound that has strong cannabinoid-like activity in both dogs and mice.
    (±)-9-Nor-9α-hydroxy Hexahydrocannabinol
  • HY-168796
    1-Palmitoyl-2-13(S)-HpODE-sn-glycero-3-PC 444997-11-9 98%
    1-Palmitoyl-2-13(S)-HpODE-sn-glycero-3-PC is a phospholipid that contains Palmitic acid (HY-N0830) and 13(S)-HpODE (HY-110406) at the sn-1 and sn-2 positions, respectively.
    1-Palmitoyl-2-13(S)-HpODE-sn-glycero-3-PC
  • HY-168797
    1,2-Dihexanoyl-sn-glycero-3-PS sodium 321862-85-5 98%
    1,2-Dihexanoyl-sn-glycero-3-PS sodium is a phospholipid containing Hexanoic acid (HY-N4078) at the sn-1 and sn-2 positions.
    1,2-Dihexanoyl-sn-glycero-3-PS sodium
  • HY-168798
    14:1 Cardiolipin sodium 2260669-33-6 98%
    14:1 Cardiolipin sodium is an anionic phospholipid containing the monounsaturated fatty acid Myristoleic acid (HY-113332).
    14:1 Cardiolipin sodium
  • HY-168804
    SOTS-1 (technical grade) 223507-96-8 98%
    SOTS-1 (technical grade) is an azo-compound that can generate superoxide radical anion.
    SOTS-1 (technical grade)
  • HY-168909
    MRK-952 98%
    MRK-952, a chemical probe, is a NUDIX hydrolase inhibitor. NUDIX enzymes are involved in cellular metabolism and homeostasis, as well as mRNA processing.
    MRK-952
Cat. No. Product Name / Synonyms Application Reactivity